Proton pump inhibitors: Considerations with long-term use. You can learn more about how we ensure our content is accurate and current by reading our editorial policy. We link primary sources - including studies, scientific references, and statistics - within each article and also list them in the resources section at the bottom of our articles. Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. Until there is more research into how PPIs affect the body over time, doctors should exercise caution when prescribing them long-term. acute interstitial nephritis, or sudden inflammation and injury of the kidneysĪlthough some of these conditions are serious, researchers note that the studies about these risks do not always prove a cause-and-effect relationship.hypomagnesemia, or very low levels of magnesium.Clostridium difficile, Campylobacter, and Salmonella infections.hypergastrinemia, or high levels of the hormone that stimulates gastric acid production.
However, long-term PPI use may carry some potential risks, including: People who experience side effects with one PPI may find that it helps to switch to a different brand. According to the International Foundation for Gastrointestinal Disorders, only 1–2% of people taking them experience any side effects.Įven though side effects are rare overall, the most common seem to be: Most people can take PPIs without any problems. Stomach acid helps release the active ingredients so that they can prevent symptoms before they start. People should take PPIs on an empty stomach before meals. This reduces heartburn and acid reflux and makes it easier for stomach ulcers to heal.Īccording to the International Foundation for Gastrointestinal Disorders, PPIs also help heal inflammation in the esophagus in 90–94% of cases. PPIs work by reducing stomach acid levels, inhibiting the amount that the parietal cells in the stomach lining can make. Less common causes of excess stomach acid include Zollinger-Ellison syndrome and stomach cancer. stomach ulcers, or a Helicobacter pylori infectionĪnxiety, smoking, and frequent alcohol consumption can also trigger heartburn and acid reflux in some people.Common underlying causes of chronic heartburn and acid reflux include: Sometimes, these symptoms will occur due to an underlying condition. Share on Pinterest A doctor may prescribe PPIs to treat heartburn or acid reflux.ĭoctors prescribe PPIs to treat stomach acid-related symptoms, such as heartburn and acid reflux.
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